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15/7/2020  
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R&D
Bacteria coated stomach tissues infected fastly

First human ´small stomachs´ created stem cell


US scientists have developed the first 3D stomach tissue made ​​from stem cells. These new miniórganos, which simulate the behavior of real, useful to study how they develop gastrointestinal diseases and produce drugs. For now, they have new tissue infected with the bacterium Helicobacter pylori, which causes ulcers and stomach cancer, and have seen how it affects the body.
Ibercampus 30/10/2014 Send to a friend
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 Scientists at Cincinnati Children´s Hospital (USA) Medical Center have reproduced human gastric tissue pluripotent stem cells capable of developing into any type of tissue. With its new ´miniestómagos´ science has from now a valuable tool to investigate how diseases related to the digestive tract, from cancer to diabetes develop.

The images of the new miniórganos, published together with the rest of the paper, in the journal Nature, shows how stem cells simulating a miniature version of a human stomach tissue.

"We have manipulated the environment in which we grow stem cells to mimic the environment of an embryo at key stages of the development of the stomach," explains Sync Jim Wells, principal investigator of the Department of Biological Development and Endocrine at Cincinnati Children´s Hospital and co-author of the study.

This is the first molecular human gastric tissue so generated. "No one had gastric generated from stem cells," Wells says. "We have discovered how to promote the formation of gastric tissue with complex three-dimensional architecture."

The key to growing the organoids was to know, step by step, the process of forming a stomach during embryo development. Simulating this process in a Petri dish, scientists forced to become stem cells in a stomach. In a month the tissue had formed, which had a size of 3 mm in diameter.

This achievement scientists studying the origin and development of diseases related to the digestive system, and to explore new avenues in drug design, the authors of the study will benefit.

"Until now, the main problem when studying stomach-related diseases has been the lack of experimental models to simulate human biology," says Wells. Mouse models have shortcomings to investigate digestive diseases of humans, species differences in embryo development and architecture of the adult stomach.

To start experimenting with miniestómagos laboratory researchers, in collaboration with the School of Medicine, University of Cincinnati, these artificial tissues infected with H. pylori, the leading cause of peptic ulcers and stomach cancer.

Impressed by the bacterium

Wells and his colleagues were impressed by the speed with which the bacterium H. pylori coated epithelial tissues which possess one or more layers of cells attached to each other-infected stomach.

After 24 hours, the bacteria were activated biochemical changes of the organ, and tissue perfectly mimic the early stages of gastric disease caused by bacteria, including activation of a gene called c-Met in cancer and the rapid spread infection in epithelial tissues.

Basic Research

The researchers had to combine work with studies already published its own laboratory to answer some basic questions about the development and training of the stomach. Wells stresses the lack of information available on basic research.

"This milestone would not have been possible if we had not disposed of previous studies by other researchers to understand the basic embryonic organ development," Wells says.

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